Scientific Innovation,

Clinically Validated

Scientific Innovation,

Clinically Validated

Promote Cellular Optimization

Improve Body Function

Promote Cellular Optimization

Improve Body Function

HiToP® High-Tone Therapy optimizes cellular performance by sending patented high-frequency, 2-dimensional, modulated waveforms through the body to energize and stimulate cells and cell particles, enhancing their function through three key effects:

Cellular Voltage
Resonance
Charged Particle Distribution

HiToP® High-Tone Therapy optimizes cellular performance by sending patented high-frequency, 2-dimensional, modulated waveforms through the body to energize and stimulate cells and cell particles, enhancing their function through three key effects:

Cellular Voltage
Resonance
Charged Particle Distribution

1. Cellular Voltage

HiToP® restores cellular voltage by directly delivering up to 5000mW energy to the body, optimizing cellular energy and “recharging the body battery”.

Higher cellular voltage improves oxygen delivery to tissues by supporting hemoglobin function and maintaining red blood cell separation, which enhances cellular energy production (ATP).

2. Resonance

HiToP® vibrates cell organelles at their unique resonance frequencies, the frequencies where they can best absorb energy.

Cell receptors and mitochondria are two of the critical organelles that are energized through resonance, enhancing their function for improved cellular performance and communication.

3. Charged Particle Distribution

HiToP® promotes the even distribution of charged particles throughout the body, facilitating cellular diffusion.

Enhanced cellular diffusion improves nutrient absorption and metabolic waste removal, elevating cellular function and overall physiological homeostasis.

Patented Advancements in Technology

HiToP® generates a patented current engineered for precise, high-energy cellular impact, defined by:

1. High Frequency for Cell Stimulation

2. Powerful Energy with Measured Absorption

3. Dynamic Current for Comprehensive Targeting

Slide 1

High Frequency to Target Tissues, Cells and Organelles

HiToP® is designed for cellular stimulation, generating high frequencies from 4000 to 32000 Hz to permeate cell membranes. Based on the physics of electrical energy, frequencies above 4000 Hz more effectively pass through tissues and cell membranes, as resistance is inversely proportional to frequency. Unlike conventional electrical stimulation modalities that max out at lower frequencies, HiToP® is the only device generating electrical frequencies above 4000 Hz, allowing it to permeate tissues and cells for targeted delivery.

Slide 1

Power Meets Precision: Up to 5000 mW with Real-Time Measurement

HiToP® delivers up to 5000 mW energy absorbable by the body, equivalent to a high-powered laser, without the risk of burns or requiring safety equipment. Precision is paramount - HiToP® displays real-time voltage, current, and energy absorbed by the body throughout each therapy session, with accurate calculation and display, unlike most other energy-based modalities that only report energy output, not true absorption.

Slide 1

Dynamic Frequencies and Amplitutde for Comprehensive Tissue Targeting

HiToP® is the only modality to generate a two-dimensional AC current with simultaneous dynamic frequencies and dynamic amplitudes, allowing for comprehensive targeting across tissues and cells - including nerve, muscle and bone - in a single therapy application. Dynamic, or modulated, frequencies target a wide range of tissue and cell types, while dynamic amplitude penetrates a wide range of tissue and cell depths. Combined, they enable HiToP® to precisely target multiple tissue types at various depths, including soft and hard tissue cells, in a single therapy session.

Backed by Numerous Scientific Studies

HiToP® High-Tone Therapy results are backed by over 30 clinical trials and case studies published in peer-reviewed scientific journals, all conducted on human patients with the HiToP® device, with benefits shown across:

Metabolic & Vascular Health

Chemical Detoxification & Kidney Function

Pain, Neurological Disorders & Neuropathy

Tissue Regeneration & Muscle Strengthening

Long COVID & Chronic Fatigue

Mental Health

Read HiToP® Studies

Metabolic & Vascular Health

“Electrical Muscle Stimulation (HiToP® high tone therapy) Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes”

Key Findings:

Decrease in diastolic blood pressure
Decrease in the frequency of hematopoietic stem cells (HSCs)
Significantly enhances the function of microvascular endothelial cells (MVECs)
Reduced plasma levels of adrenaline and noradrenaline metabolites, metanephrine and normetanephrine
Significant reduction in neuropathic pain scores
Significant reduction in diastolic blood pressure
Reduction in circulating HSCs, with an increase in VEGFR2
Enhanced vascular repair

“High Tone External Muscle Stimulation versus Aerobic Exercise on Endothelial Dysfunction and Walking Parameters in Peripheral Arterial Disease”

Key Findings:

Improvement of endothelial function
Improvement of walking capacity
Alternative modality to exercise

University Hospital Heidelberg - Clinical Study

“High frequent muscle stimulation (HiToP® high tone therapy) as a treatment for painful neuropathy for type 2 diabetes improves the micro vascular endothelial cell function”

Key Findings:

Improvement of endothelial function
Significant reduction in neuropathic pain scores

“External electric muscle stimulation (HiToP® high tone therapy) improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.”

Key Findings:

Decline in HbA1c levels
Decrease in Body Mass Index (BMI)
Significantly reduced burning sensations
Improved sleep disturbances
Improved neuropathy symptoms, pain relief, paresthesia

Conference of the German Diabetes Society - Clinical Study

“External Muscle Stimulation (HiToP® high tone therapy) to Influence Adjustment of Diabetes: a New Therapy Option for Type 2 Diabetics”

Key Findings:

Notable decreases in body weight
Decrease in BMI
Significant reductions in HbA1c levels
Improved glycemic control

“Effect of High Tone Power Therapy (HiToP®) on Neurological Symptoms and Functional Outcome in Patients with Diabetic Neuropathy”

Key Findings:

Significant improvement in HbA1c levels
Improvement in glycemic control
Improvement in Neurological Symptoms
Enhanced Functional Outcomes
Improvement in Katz scale

“Beneficial effects of external muscle stimulation (HiToP® high tone therapy) on glycemic control in patients with type 2 diabetes”

Key Findings:

HbA1c levels decreased significantly
Serum C-peptide levels and HOMA-IR (measures of insulin resistance) decreased
Body weight decreased significantly
BMI decreased significantly

Conference of the German Diabetes Society - Clinical Study

“New Possibilities for the Treatment of Type 2 Diabetes Mellitus by Means of External Electrical Muscle Stimulation (HiToP® high tone therapy)”

Key Findings:

Reduction in body weight
Decrease in Body Mass Index (BMI)
Decline in HbA1c levels

Chemical Detoxification & Kidney Function

“Effects of high-tone External Muscle Stimulation on renal function in Healthy Volunteers”

Key Findings:

Significant increase of creatinine clearance
Significant increase of fractional sodium excretion

“Muscle Stimulation (HiToP® high tone therapy) in elderly patients with CKD and sarcopenia”

Key Findings:

Improved microcirculation
Reduced kidney damage

“Effect of High Tone Therapy on Selective Kidney functions in Hemodialysis Patients”

Key Findings:

Significant decrease of Urea and Creatinine

“High-Tone external Muscle Stimulation (HiToP® high tone therapy) in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.”

Key Findings:

Improved kidney function
Faster normalization of lowered NOx
Elevated ADMA and ET-1 plasma levels
Accelerated recovery of AKI

Pain, Neurological Disorders & Neuropathy

“The Impact of High Tone Power Therapy on Pain and Functional Abilities of Diabetic Patients with Lumbar Radiculopathy”

Key Findings:

Disability Index scores and functional abilities improved significantly
Substantial reduction in pain
Improvement in neurophysiological measures

“Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation (HiToP® high tone therapy)”

Key Findings:

Significant reduction of neuropathic pain

“Comparison of high tone therapy and transcutaneous electrical nerve stimulation therapy in chemotherapy-induced polyneuropathy”

Key Findings:

Significant reduction in chemotherapy-induced neuropathic pain

“Electrotherapy (HiToP® high tone therapy) as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial”

Key Findings:

Successful results in improving CIPN-related sensory impairment for chemotherapy-induced Neuropathy
Improved kidney function

“The influence of high tone power therapy on the functional status of patients with multiple sclerosis”

Key Findings:

Beneficial effect on the functional status of patients with MS
Positive outcomes across various parameters

“High-Tone External Muscle Stimulation (HiToP® high tone therapy) for the Treatment of Chronic Sciatica – A Randomized Controlled Crossover Trial”

Key Findings:

Chronic sciatica pain significantly reduced

“Effect Of High Tone Power Therapy On Carpal Tunnel Syndrome Patients: (Randomized Controlled Trial)”

Key Findings:

Decreased pain
Improved function outcome

“Effect of high tone power therapy on neurophysiological measures and function outcome in patients with diabetic neuropathy”

Key Findings:

Improved neurophysiological measures
Improved function outcomes

“High-tone external muscle stimulation (HiToP® high tone therapy) in end-stage renal disease: effects on quality of life in patients with peripheral neuropathy”

Key Findings:

Decreased pain associated with both diabetic and uremic neuropathy
Significant reduction in sleep disturbances
Significant improvement in all five neuropathic symptoms

Tissue Regeneration & Muscle Strengthening

“The application of high-tone power therapy in the rehabilitation of patients with soft-tissue damage to the knee joint”

Key Findings:

Improved knee injury regeneration

“Validation Of High-Tone Therapy To Increase Maximum Strength And Endurance”

Key Findings:

Muscle regeneration
Increased strength performance
More efficient protein biosynthesis on arm muscles

“Quadriceps muscle strength recovery with the use of high tone power therapy after anterior cruciate ligament reconstruction: a randomized controlled trial”

Key Findings:

Significant improvement in muscle torque and knee circumference
Significant improvement in thigh circumference, and knee extension
Beneficial effect on muscle strength, reduction of joint effusion
Beneficial effect on muscle mass gain and joint function

“High-Frequency External Muscle Stimulation (HiToP® high tone therapy) Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”

Key Findings:

Significant improvements in depression, anxiety, and muscle strength

“The influence of high tone power therapy on the peripheral microcirculation in the lower limbs”

Key Findings:

Significant increase of blood flow

“The effect of high-tone external muscle stimulation on symptoms and electrophysiological parameters of uremic peripheral neuropathy”

Key Findings:

Regeneration of myelin sheaths
Nerve Regeneration

Clinical Study

“Testing of improved regeneration and increased strength through High Tone therapy”

Key Findings:

Significant improvement in Arm Muscle Strength

The Central European Journal of Medicine

“Conservative treatment of knee arthrofibrosis according to a cellular cytokine-based mode”

Key Findings:

HiToP is highlighted as an effective solution

Long COVID & Chronic Fatigue

“Effect of High Tone Power Therapy on Selected Symptoms in Post Covid Syndrome (WHO)”

Key Findings:

Significant decrease of fatigue
Improved dyspnea score
Improved quality of sleep
Improved submaximal exercise capacity

“Positive effect of high tone power therapy on the functional capacity of patients with Post-COVID condition – a pilot study”

Key Findings:

Improved Functional Capacity
Significantly Improved Physical Summary Score (PSS)
Significantly Improved Mental Summary Score (MSS)
Improved Work Ability Index (WAI)
Significantly improved 1-Minute Sit to Stand Test (1-MSTST)

Mental Health

“The effectiveness of high-tone therapy in the complex rehabilitation of servicemen with post-traumatic stress disorder complicated by traumatic brain injury”

Key Findings:

Increased alpha rhythm and reduced slow rhythms
Improved PTSD and anxiety

“High-Frequency External Muscle Stimulation (HiToP® high tone therapy) Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”

Key Findings:

Significant improvements in depression and anxiety

Balneo and PRM Research Journal

“Evaluation of the impact of high-tone therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology”

Key Findings:

Improved cognitive functions
Reduced anxiety and depression
Improved quality of life

Mental Health Hospital - Clinical Study

“Comparison of GBO HiToP (HiToP® high tone therapy) against conventional ECT machine from Siemens as a treatment against Mentally disabled patient.”

Key Findings:

Comfortable and effective treatment for Schizophrenia
Comfortable and effective treatment for Vegetative State
Comfortable and effective treatment for Anxiety
Comfortable and effective treatment for Depression

CLEARED

Class II Medical Device

MARKED

Certified European Medical Device Regulations

PATENTED

Holding 3 international patents

The safety of HiToP® technology has been evaluated and cleared by the FDA, as has its effectiveness for specific indications. HiToP® is intended for use in the U.S. under FDA clearance for:

Symptomatic relief and management of chronic, intractable pain
Relaxation of muscle spasms
Prevention or retardation of disuse atrophy
Increase local blood circulation
Muscle re-education
Maintaining or increasing the range of motion
Immediate post-surgical stimulation of calf muscles to prevent venous thrombosis