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Scientific Publications

Explore the published clinical literature behind HiToP® High-Tone Therapy, including peer-reviewed studies, case reports, and scientific findings across multiple areas of human health and physiological function.

All studies were conducted on HiToP® High-Tone Therapy devices across human subjects.

Read HiToP® Studies

Metabolic & Vascular Health

“Electrical Muscle Stimulation (HiToP® high tone therapy) Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes”

Key Findings:

  • Decrease in diastolic blood pressure
  • Decrease in the frequency of hematopoietic stem cells (HSCs)
  • Significantly enhances the function of microvascular endothelial cells (MVECs)
  • Reduced plasma levels of adrenaline and noradrenaline metabolites, metanephrine and normetanephrine
  • Significant reduction in neuropathic pain scores
  • Significant reduction in diastolic blood pressure
  • Reduction in circulating HSCs, with an increase in VEGFR2
  • Enhanced vascular repair

“High Tone External Muscle Stimulation versus Aerobic Exercise on Endothelial Dysfunction and Walking Parameters in Peripheral Arterial Disease”

Key Findings:

  • Improvement of endothelial function
  • Improvement of walking capacity
  • Alternative modality to exercise

University Hospital Heidelberg - Clinical Study

“High frequent muscle stimulation (HiToP® high tone therapy) as a treatment for painful neuropathy for type 2 diabetes improves the micro vascular endothelial cell function”

Key Findings:

  • Improvement of endothelial function
  • Significant reduction in neuropathic pain scores

“External electric muscle stimulation (HiToP® high tone therapy) improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.”

Key Findings:

  • Decline in HbA1c levels
  • Decrease in Body Mass Index (BMI)
  • Significantly reduced burning sensations
  • Improved sleep disturbances
  • Improved neuropathy symptoms, pain relief, paresthesia

Conference of the German Diabetes Society - Clinical Study

“External Muscle Stimulation (HiToP® high tone therapy) to Influence Adjustment of Diabetes: a New Therapy Option for Type 2 Diabetics”

Key Findings:

  • Notable decreases in body weight
  • Decrease in BMI
  • Significant reductions in HbA1c levels
  • Improved glycemic control

“Effect of High Tone Power Therapy (HiToP®) on Neurological Symptoms and Functional Outcome in Patients with Diabetic Neuropathy”

Key Findings:

  • Significant improvement in HbA1c levels
  • Improvement in glycemic control
  • Improvement in Neurological Symptoms
  • Enhanced Functional Outcomes
  • Improvement in Katz scale

“Beneficial effects of external muscle stimulation (HiToP® high tone therapy) on glycemic control in patients with type 2 diabetes”

Key Findings:

  • HbA1c levels decreased significantly
  • Serum C-peptide levels and HOMA-IR (measures of insulin resistance) decreased
  • Body weight decreased significantly
  • BMI decreased significantly

Conference of the German Diabetes Society - Clinical Study

“New Possibilities for the Treatment of Type 2 Diabetes Mellitus by Means of External Electrical Muscle Stimulation (HiToP® high tone therapy)”

Key Findings:

  • Reduction in body weight
  • Decrease in Body Mass Index (BMI)
  • Decline in HbA1c levels

Chemical Detoxification & Kidney Function

“Effects of high-tone External Muscle Stimulation on renal function in Healthy Volunteers”

Key Findings:

  • Significant increase of creatinine clearance
  • Significant increase of fractional sodium excretion

“Muscle Stimulation (HiToP® high tone therapy) in elderly patients with CKD and sarcopenia”

Key Findings:

  • Improved microcirculation
  • Reduced kidney damage

“Effect of High Tone Therapy on Selective Kidney functions in Hemodialysis Patients”

Key Findings:

  • Significant decrease of Urea and Creatinine

“High-Tone external Muscle Stimulation (HiToP® high tone therapy) in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.”

Key Findings:

  • Improved kidney function
  • Faster normalization of lowered NOx
  • Elevated ADMA and ET-1 plasma levels
  • Accelerated recovery of AKI

Pain, Neurological Disorders & Neuropathy

“The Impact of High Tone Power Therapy on Pain and Functional Abilities of Diabetic Patients with Lumbar Radiculopathy”

Key Findings:

  • Disability Index scores and functional abilities improved significantly
  • Substantial reduction in pain
  • Improvement in neurophysiological measures

“Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation (HiToP® high tone therapy)”

Key Findings:

  • Significant reduction of neuropathic pain

“Comparison of high tone therapy and transcutaneous electrical nerve stimulation therapy in chemotherapy-induced polyneuropathy”

Key Findings:

  • Significant reduction in chemotherapy-induced neuropathic pain

“Electrotherapy (HiToP® high tone therapy) as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial”

Key Findings:

  • Successful results in improving CIPN-related sensory impairment for chemotherapy-induced Neuropathy
  • Improved kidney function

“The influence of high tone power therapy on the functional status of patients with multiple sclerosis”

Key Findings:

  • Beneficial effect on the functional status of patients with MS
  • Positive outcomes across various parameters

“High-Tone External Muscle Stimulation (HiToP® high tone therapy) for the Treatment of Chronic Sciatica – A Randomized Controlled Crossover Trial”

Key Findings:

  • Chronic sciatica pain significantly reduced

“Effect Of High Tone Power Therapy On Carpal Tunnel Syndrome Patients: (Randomized Controlled Trial)”

Key Findings:

  • Decreased pain
  • Improved function outcome

“Effect of high tone power therapy on neurophysiological measures and function outcome in patients with diabetic neuropathy”

Key Findings:

  • Improved neurophysiological measures
  • Improved function outcomes

“High-tone external muscle stimulation (HiToP® high tone therapy) in end-stage renal disease: effects on quality of life in patients with peripheral neuropathy”

Key Findings:

  • Decreased pain associated with both diabetic and uremic neuropathy
  • Significant reduction in sleep disturbances
  • Significant improvement in all five neuropathic symptoms

Tissue Regeneration & Muscle Strengthening

“The application of high-tone power therapy in the rehabilitation of patients with soft-tissue damage to the knee joint”

Key Findings:

  • Improved knee injury regeneration

“Validation Of High-Tone Therapy To Increase Maximum Strength And Endurance”

Key Findings:

  • Muscle regeneration
  • Increased strength performance
  • More efficient protein biosynthesis on arm muscles

“Quadriceps muscle strength recovery with the use of high tone power therapy after anterior cruciate ligament reconstruction: a randomized controlled trial”

Key Findings:

  • Significant improvement in muscle torque and knee circumference
  • Significant improvement in thigh circumference, and knee extension
  • Beneficial effect on muscle strength, reduction of joint effusion
  • Beneficial effect on muscle mass gain and joint function

“High-Frequency External Muscle Stimulation (HiToP® high tone therapy) Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”

Key Findings:

  • Significant improvements in depression, anxiety, and muscle strength

“The influence of high tone power therapy on the peripheral microcirculation in the lower limbs”

Key Findings:

  • Significant increase of blood flow

“The effect of high-tone external muscle stimulation on symptoms and electrophysiological parameters of uremic peripheral neuropathy”

Key Findings:

  • Regeneration of myelin sheaths
  • Nerve Regeneration

Clinical Study

“Testing of improved regeneration and increased strength through High Tone therapy”

Key Findings:

  • Significant improvement in Arm Muscle Strength

The Central European Journal of Medicine

“Conservative treatment of knee arthrofibrosis according to a cellular cytokine-based mode”

Key Findings:

  • HiToP is highlighted as an effective solution

Long COVID & Chronic Fatigue

“Effect of High Tone Power Therapy on Selected Symptoms in Post Covid Syndrome (WHO)”

Key Findings:

  • Significant decrease of fatigue
  • Improved dyspnea score
  • Improved quality of sleep
  • Improved submaximal exercise capacity

“Positive effect of high tone power therapy on the functional capacity of patients with Post-COVID condition – a pilot study”

Key Findings:

  • Improved Functional Capacity
  • Significantly Improved Physical Summary Score (PSS)
  • Significantly Improved Mental Summary Score (MSS)
  • Improved Work Ability Index (WAI)
  • Significantly improved 1-Minute Sit to Stand Test (1-MSTST)

Mental Health

“The effectiveness of high-tone therapy in the complex rehabilitation of servicemen with post-traumatic stress disorder complicated by traumatic brain injury”

Key Findings:

  • Increased alpha rhythm and reduced slow rhythms
  • Improved PTSD and anxiety

“High-Frequency External Muscle Stimulation (HiToP® high tone therapy) Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”

Key Findings:

  • Significant improvements in depression and anxiety

Balneo and PRM Research Journal

“Evaluation of the impact of high-tone therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology”

Key Findings:

  • Improved cognitive functions
  • Reduced anxiety and depression
  • Improved quality of life

Mental Health Hospital - Clinical Study

“Comparison of GBO HiToP (HiToP® high tone therapy) against conventional ECT machine from Siemens as a treatment against Mentally disabled patient.”

Key Findings:

  • Comfortable and effective treatment for Schizophrenia
  • Comfortable and effective treatment for Vegetative State
  • Comfortable and effective treatment for Anxiety
  • Comfortable and effective treatment for Depression
The safety of HiToP® technology has been evaluated and cleared by the FDA, as has its effectiveness for specific indications. HiToP® is intended for use in the U.S. under FDA clearance for:

  • Symptomatic relief and management of chronic, intractable pain
  • Relaxation of muscle spasms
  • Prevention or retardation of disuse atrophy
  • Increase local blood circulation
  • Muscle re-education
  • Maintaining or increasing the range of motion
  • Immediate post-surgical stimulation of calf muscles to prevent venous thrombosis