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Discover HiToP® PNP

HiToP® High-Tone Technology, Purpose-Built for Neuropathy Care

Discover HiToP® PNP

HiToP® High-Tone Technology, Purpose-Built for Neuropathy Care

Reduce Numbness. Reduce Pain.

Feel Your Feet Again.

An Advanced Neuropathy Solution

Built on the HiToP® High-Tone Therapy Platform

HiToP® PNP utilizes the same patented High-Tone Therapy technology found in the HiToP® Touch systems.

While the Touch platform offers a wide range of clinical applications, HiToP® PNP has been specifically configured for neuropathy-focused treatment protocols, providing practices with an accessible solution dedicated to nerve health, circulation, and neuropathy care.

CLEARED

Class II Medical Device

MARKED

Certified European Medical Device Regulations

HiToP® PNP: Comprehensive Neuropathy Therapy

HiToP® PNP’s patented two-dimensional frequency SimulFAM® targets nerves, muscles, and cells to support circulation, cellular metabolism, vascular health, and nerve function.

Nerve Stimulation

Vertical oscillations stimulate C-fibers to help reduce neuropathic pain, numbness, and abnormal sensations.

Muscle Activation

Deep muscle contractions in the lower extremities increase glucose utilization, promote circulation, and engage the skeletal muscle pump.

Cellular Stimulation

Horizontal oscillations penetrate cell membranes to energize organelles, enhance receptor function, and regulate cellular activity.

Clinically Shown in Published Scientific Studies to Improve:

Pain & Sensation

  • Reduce painful sensations
  • Reduce paresthesia
  • Reduce burning sensations
  • Decrease sleep disturbances

Metabolic Health

  • Improve glycemic control
  • Reduce HbA1C levels
  • Decrease insulin resistance
  • Reduce serum C-peptide levels and HOMA-IR markers

Vascular Health

  • Enhance microcirculation
  • Promote vasodilation
  • Encourage greater capillary perfusion
  • Improve endothelial function

Kidney Function

  • Enhance renal clearance (creatinine clearance)
  • Improve fluid regulation (increase fractional sodium excretion)
  • Optimize kidney function

Results include those shown across patients with Diabetic Neuropathy, Chemotherapy-Induced Neuropathy, and CMT

Diabetic Neuropathy

Comprehensive Treatment Requires More Than Just Pain Relief

As Type 2 Diabetes progresses through its chronic stages, sustained hyperglycemia causes severe damage to both the macro- and microvasculature. This deterioration of microcirculation – the network of tiny capillaries responsible for delivering oxygen and nutrients – restricts vital blood flow to end organs like the kidneys, leading to nephropathy, and to the small blood vessels (vasa nervorum) that supply the nerves.

This lack of oxygen triggers diabetic polyneuropathy (PNP), localized fluid retention, swelling, and severe vascular insufficiency. Patients frequently experience these systemic stages as debilitating lower extremities pain, accompanied by constant numbness, burning, and a “pins and needles” tingling sensation in the feet. Left unchecked, this loss of sensation and impaired microvascular healing capacity significantly increases the risk of developing chronic feet wounds and non-healing ulcers.

To combat these interrelated symptoms at their core, targeted medical intervention is required. HiToP® PNP is a non-invasive, holistic therapy that addresses these interrelated issues at their source – supporting circulation, cellular metabolism, vascular health, muscle activity and nerve function. For patients with limited exercise tolerance, it provides a therapeutic means of activating key physiological systems involved in vascular and and metabolic health.

Read Studies with HiToP® PNP Technology

“Electrical Muscle Stimulation (HiToP® high tone therapy) Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes”

Key Findings:

  • Decrease in diastolic blood pressure
  • Decrease in the frequency of hematopoietic stem cells (HSCs)
  • Significantly enhances the function of microvascular endothelial cells (MVECs)
  • Reduced plasma levels of adrenaline and noradrenaline metabolites, metanephrine and normetanephrine
  • Significant reduction in neuropathic pain scores
  • Significant reduction in diastolic blood pressure
  • Reduction in circulating HSCs, with an increase in VEGFR2
  • Enhanced vascular repair

“High Tone External Muscle Stimulation versus Aerobic Exercise on Endothelial Dysfunction and Walking Parameters in Peripheral Arterial Disease”

Key Findings:

  • Improvement of endothelial function
  • Improvement of walking capacity
  • Alternative modality to exercise

University Hospital Heidelberg - Clinical Study

“High frequent muscle stimulation (HiToP® high tone therapy) as a treatment for painful neuropathy for type 2 diabetes improves the micro vascular endothelial cell function”

Key Findings:

  • Improvement of endothelial function
  • Significant reduction in neuropathic pain scores

“External electric muscle stimulation (HiToP® high tone therapy) improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.”

Key Findings:

  • Decline in HbA1c levels
  • Decrease in Body Mass Index (BMI)
  • Significantly reduced burning sensations
  • Improved sleep disturbances
  • Improved neuropathy symptoms, pain relief, paresthesia

Conference of the German Diabetes Society - Clinical Study

“External Muscle Stimulation (HiToP® high tone therapy) to Influence Adjustment of Diabetes: a New Therapy Option for Type 2 Diabetics”

Key Findings:

  • Notable decreases in body weight
  • Decrease in BMI
  • Significant reductions in HbA1c levels
  • Improved glycemic control

“Effect of High Tone Power Therapy (HiToP®) on Neurological Symptoms and Functional Outcome in Patients with Diabetic Neuropathy”

Key Findings:

  • Significant improvement in HbA1c levels
  • Improvement in glycemic control
  • Improvement in Neurological Symptoms
  • Enhanced Functional Outcomes
  • Improvement in Katz scale

“Beneficial effects of external muscle stimulation (HiToP® high tone therapy) on glycemic control in patients with type 2 diabetes”

Key Findings:

  • HbA1c levels decreased significantly
  • Serum C-peptide levels and HOMA-IR (measures of insulin resistance) decreased
  • Body weight decreased significantly
  • BMI decreased significantly

Conference of the German Diabetes Society - Clinical Study

“New Possibilities for the Treatment of Type 2 Diabetes Mellitus by Means of External Electrical Muscle Stimulation (HiToP® high tone therapy)”

Key Findings:

  • Reduction in body weight
  • Decrease in Body Mass Index (BMI)
  • Decline in HbA1c levels

“Effects of high-tone External Muscle Stimulation on renal function in Healthy Volunteers”

Key Findings:

  • Significant increase of creatinine clearance
  • Significant increase of fractional sodium excretion

“Muscle Stimulation (HiToP® high tone therapy) in elderly patients with CKD and sarcopenia”

Key Findings:

  • Improved microcirculation
  • Reduced kidney damage

“Effect of High Tone Therapy on Selective Kidney functions in Hemodialysis Patients”

Key Findings:

  • Significant decrease of Urea and Creatinine

“High-Tone external Muscle Stimulation (HiToP® high tone therapy) in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.”

Key Findings:

  • Improved kidney function
  • Faster normalization of lowered NOx
  • Elevated ADMA and ET-1 plasma levels
  • Accelerated recovery of AKI

“The Impact of High Tone Power Therapy on Pain and Functional Abilities of Diabetic Patients with Lumbar Radiculopathy”

Key Findings:

  • Disability Index scores and functional abilities improved significantly
  • Substantial reduction in pain
  • Improvement in neurophysiological measures

“Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation (HiToP® high tone therapy)”

Key Findings:

  • Significant reduction of neuropathic pain

“Comparison of high tone therapy and transcutaneous electrical nerve stimulation therapy in chemotherapy-induced polyneuropathy”

Key Findings:

  • Significant reduction in chemotherapy-induced neuropathic pain

“Electrotherapy (HiToP® high tone therapy) as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial”

Key Findings:

  • Successful results in improving CIPN-related sensory impairment for chemotherapy-induced Neuropathy
  • Improved kidney function

“Effect of high tone power therapy on neurophysiological measures and function outcome in patients with diabetic neuropathy”

Key Findings:

  • Improved neurophysiological measures
  • Improved function outcomes

“High-tone external muscle stimulation (HiToP® high tone therapy) in end-stage renal disease: effects on quality of life in patients with peripheral neuropathy”

Key Findings:

  • Decreased pain associated with both diabetic and uremic neuropathy
  • Significant reduction in sleep disturbances
  • Significant improvement in all five neuropathic symptoms

“The influence of high tone power therapy on the peripheral microcirculation in the lower limbs”

Key Findings:

  • Significant increase of blood flow

For Therapies In Addition To Neuropathy, Explore the HiToP® Touch Series

While HiToP® PNP is designed specifically for neuropathy applications, the HiToP® Touch series provides a broader range of clinical applications across functional medicine, wellness and longevity, and sports medicine.
Explore HiToP® Touch

Which HiToP® System Is Right For Your Practice?

HiToP® Touch

HiToP® PNP

Multiple therapeutic applications

Whole-body and local treatments

Available in 1, 2, or 4 channel configurations

Ideal for practices seeking maximum versatility

Dedicated neuropathy-focused device

Streamlined workflow and protocol design

Lower investment entry point

Ideal for practices looking to add neuropathy services

For Therapies In Addition To Neuropathy, Explore the HiToP® Touch Series

While HiToP® PNP is designed specifically for neuropathy applications, the HiToP® Touch series provides a broader range of clinical applications across functional medicine, wellness and longevity, and sports medicine.
Explore HiToP® Touch

Which HiToP® System Is Right For Your Practice?

HiToP® Touch

Multiple therapeutic applications

Whole-body and local treatments

Available in 1, 2, or 4 channel configurations

Ideal for practices seeking maximum versatility

HiToP® PNP

Dedicated neuropathy-focused device

Streamlined workflow and protocol design

Lower investment entry point

Ideal for practices looking to add neuropathy services

The safety of HiToP® technology has been evaluated and cleared by the FDA, as has its effectiveness for specific indications. HiToP® PNP is intended for use in the U.S. under FDA clearance for:

  • Adjunctive use in adults to provide temporary relief of pain associated with mild to moderate diabetic peripheral neuropathy of the lower extremities
  • Increase local blood circulation
  • Muscle re-education
  • Relaxation of muscle spasms
  • Maintaining or increasing range of motion