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Clinical Research and Case Studies Conducted Using HiToP®

HiToP® technology is backed by over 30 clinical trials and case studies published in peer-reviewed scientific journals, consistently demonstrating its safety, efficacy, and therapeutic potential across a range of clinical applications.

Metabolic Health     Vascular Health     Tissue Repair

Publisher Study and Findings Link
“Electrical Muscle Stimulation Induces an Increase of VEGFR2 on Circulating Hematopoietic Stem Cells in Patients With Diabetes”
  • Decrease in diastolic blood pressure from 80 to 70 mm Hg
  • Decrease in the frequency of hematopoietic stem cells (HSCs)
  • Significantly enhances the function of microvascular endothelial cells (MVECs)
  • Reduced plasma levels of adrenaline and noradrenaline metabolites, metanephrine and normetanephrine
  • Significant reduction in neuropathic pain scores
  • Significant reduction in diastolic blood pressure
  • Reduction in circulating HSCs, with an increase in VEGFR2 Enhanced vascular repair
 Link
“High Tone External Muscle Stimulation versus Aerobic Exercise on Endothelial Dysfunction and Walking Parameters in Peripheral Arterial Disease”
  • Improvement of endothelial function
  • Improvement of walking capacity
  • Alternative modality to exercise
 Link

Clinical Study

 “High frequent muscle stimulation as a treatment for painful neuropathy for type 2 diabetes improves the micro vascular endothelial cell function”
  • Improvement of endothelial function
  • Significant reduction in neuropathic pain scores
Case Study
“External electric muscle stimulation (HiToP® therapy) improves burning sensations and sleeping disturbances in patients with type 2 diabetes and symptomatic neuropathy.”
  • Reduced significantly burning sensations
  • Improved sleep disturbances
  • Improved neuropathy symptoms, pain relief, paresthesia
  • A decrease in Body Mass Index (BMI)
  • A decline in HbA1c levels
Link

Clinical Study

Conference of the German Diabetes Society		 “External Muscle Stimulation to Influence Adjustment of Diabetes: a New Therapy Option for Type 2 Diabetics.”
  • Notable decreases in body weight
  • Decrease in BMI
  • Significant reductions in HbA1c levels
  • Improved glycemic control
Case Study
“The effectiveness of High Tone Therapy (HiToP®) was evaluated in patients with diabetic neuropathy.”
  • Improvement in Neurological Symptoms
  • Enhanced Functional Outcomes
  • Significant improvement in HbA1c levels
  • Improvement in glycemic control
  • Improvement in Katz scale (72.08%)
Link
“Beneficial effects of external muscle stimulation on glycemic control in patients with type 2 diabetes.”
  • Body weight decreased significantly (-1.2 kg on average)
  • BMI decreased significantly (-0.4 kg/m² on average)
  • HbA1c levels decreased significantly (-0.4% on average)
  • Serum C-peptide levels and HOMA-IR (measures of insulin resistance) decreased
Link

Clinical Study

Conference of the German Diabetes Society		 “HiToP® may be effective in promoting weight loss and improving glycemic control in participants.”
  • A reduction in body weight by 1.4 kg
  • A decrease in Body Mass Index (BMI) by 0.6 kg/m²
  • A decline in HbA1c levels by 0.6%
Case Study

Mental Health

Publisher Study and Findings Link
“The effectiveness of high-tone therapy in the complex rehabilitation of servicemen with post-traumatic stress disorder complicated by traumatic brain injury”
  • Increased alpha rhythm and reduced slow rhythms
  • Improved PTSD and anxiety
 Link
“High-Frequency External Muscle Stimulation Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”
  • Significant improvements in depression and anxiety
 Link
“Evaluation of the impact of high-tone therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology”
  • Improved cognitive functions
  • Reduced anxiety and depression
  • Improved quality of life
 Link

Clinical Study

 “Comparison of GBO HiTOP against conventional ECT machine from Siemens as a treatment against Mentally disabled patient.”
  • Comfortable and effective treatments for Schizophrenia
  • Comfortable and effective treatments Vegetative
  • Comfortable and effective treatments Anxiety
  • Comfortable and effective treatments Depression
Case Study

Chemical Detoxification      Kidney Function  

Publisher Study and Findings Link
“Effects of high-tone External Muscle Stimulation on renal function in Healthy Volunteers”
  • Significant increase of creatinine clearance
  • Significant increase of fractional sodium excretion
 Link
“Muscle Stimulation in elderly patients with CKD and sarcopenia”
  • Improved microcirculation and reduced kidney damage
 Link
“Effect of High Tone Therapy on Selective Kidney functions in Hemodialysis Patients”
  • Significant decrease of Urea and Creatinine
  • Improved ureal and creatinine level in hemodialysis patients
 Link
“High-Tone external Muscle Stimulation in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1.”
  • Improved kidney function
  • Faster normalization of lowered NOx
  • Elevated ADMA and ET-1 plasma levels
  • Accelerated recovery of AKI
Link

Pain     Neurological Disorders      Neuropathy

Publisher Study and Findings Link
“The Impact of High Tone Power Therapy on Pain and Functional Abilities of Diabetic Patients with Lumbar Radiculopathy.”
  • Disability Index scores and functional abilities improved significantly
  • Substantial reduction in pain
  • Improvement in neurophysiological measures
 Link
“Effective treatment of symptomatic diabetic polyneuropathy by high-frequency external muscle stimulation”
  • Significant reduction of neuropathic pain
 Link
“Comparison of high tone therapy and transcutaneous electrical nerve stimulation therapy in chemotherapy-induced polyneuropathy”
  • Significant reduction in chemotherapy-induced neuropathic pain
 Link
“Electrotherapy as treatment for chemotherapy-induced peripheral neuropathy — a randomized controlled trial”
  • Improved kidney function
  • Successful results in improving CIPN-related sensory impairment for chemotherapy-induced Neuropathy
 Link
“The influence of high tone power therapy on the functional status of patients with multiple sclerosis”
  • Beneficial effect on the functional status of patients with MS
  • Positive outcomes across various parameters
 Link
“High-Tone External Muscle Stimulation for the Treatment of Chronic Sciatica – A Randomized Controlled Crossover Trial”
  • Chronic sciatica pain significantly reduced
 Link
“Effect Of High Tone Power Therapy On Carpal Tunnel Syndrome Patients: (Randomized Controlled Trial)”
  • Decreasing pain
  • Improving function outcome
 Link
“Effect of high tone power therapy on neurophysiological measures and function outcome in patients with diabetic neuropathy”
  • Improved neurophysiological measures in diabetic neuropathy patients
  • Improved function outcomes in diabetic neuropathy patients
 Link
“High-tone external muscle stimulation in end-stage renal disease: effects on quality of life in patients with peripheral neuropathy”
  • Decreased pain associated with both diabetic and uremic neuropathy
  • Significant reduction in sleep disturbances
  • Significant improvement in all five neuropathic symptoms
 Link

Tissue Regeneration    Muscle Strengthening 

Publisher Study and Findings Link
“The application of high-tone power therapy in the rehabilitation of patients with soft-tissue damage to the knee joint”
  • Improved knee Injury regeneration
Link
“Validation Of High-Tone Therapy To Increase Maximum Strength And Endurance”
  • Muscle regeneration
  • Increased strength performance
  • More efficient protein biosynthesis on arm muscles
 Link
“Quadriceps muscle strength recovery with the use of high tone power therapy after anterior cruciate ligament reconstruction: a randomized controlled trial”
  • Significant improvement in muscle torque and knee circumference
  • Significant improvement in thigh circumference, and knee extension
  • Beneficial effect on muscle strength, reduction of joint effusion
  • Beneficial effect on muscle mass gain and joint function
Link
“High-Frequency External Muscle Stimulation Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study”
  • Significant improvements in depression, anxiety, and muscle strength
 Link
“Electrical The influence of high tone power therapy on the peripheral microcirculation in the lower limbs”
  • Significant increase of the blood flow
 Link
“The effect of high-tone external muscle stimulation on symptoms and electrophysiological parameters of uremic peripheral neuropathy”
  • Regeneration of myelin sheaths
  • Nerve Regeneration
 Link

Clinical Study

 “Testing of improved regeneration and increased strength through High Tone therapy”
  • Significant improvement in Arm Muscle Strength
 Case Study

Clinical Study

 “Conservative treatment of knee arthrofibrosis according to a cellular cytokine-based mode”
  • HiToP is highlighted as an effective solution
 Link

LONG COVID    Chronic fatigue

Publisher Study and Findings Link
"Post (long) - Covid Syndrome: ANew Concept Of Rehabilitation”
  • Significant decrease of fatigue
  • Improved dyspnea score
  • Improved quality of sleep
  • Improved submaximal exercise capacity
 Link