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Clinical Research and Case Studies Conducted Using HiToP®

Metabolic Health    Neurological Disorders    Chronic Pain

Author Source Title Links
L. Reichstein et al. Diabetologia (2005) 48: 824–828 Effective Treatment of Symptomatic Diabetic polyneuropathy by High-Frequency External Muscle Stimulation Link
M. Lankisch et al. German Diabetes Center, Poster presentation, Autumn Meeting of the Association of Diabetologists in Private Practice 2005 New Possibilities for The Treatment of Type 2 Diabetes Mellitus by Means of External Electrical Muscle Stimulation Link
M. Humpert et al. Poster presentation, Conference of the German Diabetes Society 2006 High Frequent Muscle Stimulation as a Treatment for Painful Neuropathy for Type 2 Diabetes Improves the Microvascular Endothelial Cell Function Link
Bettina Rose et al. Poster Presentation at the German Diabetes Conference 2007 External Muscle Stimulation to Influence Adjustment of Diabetes: a New Therapy Option for Type 2 Diabetics Link
K. Kempf et al. Diabetologie und Stoffwechsel 2008; 3 DOI: 10.1055/s-2008-1076201 Muskelstimulation mit Hoch-Frequenter Externer Muskelstimulation Mindert Signifikant die Symptome der Diabetischen Polyneuropathie Link
M. Humpert et al. Pain Medicine Volume 10 Issue 2 (March 2009) External Electric Muscle Stimulation Improves Burning Sensations and Sleeping Disturbances in Patients with Type 2 Diabetes and Symptomatic Neuropathy Link
A. Klassen et al. Journal of Renal Nutrition 2008; 18(1). High-Tone External Muscle Stimulation in End-Stage Renal Disease: Effects on Symptomatic Diabetic and Uremic Peripheral Polyneuropathy Link
W. K. M. Abo El-Regal et al. Egypt. J. of Appl. Sci., 36 (1) 2021: 10-21. Effect of High One Therapy on Neurological Symptoms and Functional Outcome in Patients with Diabetic Neuropathy Link
Robert Wakolbinger et al. Supportive Care in Cancer (2024) 32:134 Home‐based high Tone therapy may alleviate chemotherapy‐induced neuropathic symptoms in patients with colorectal cancer: A randomized double‐blind placebo‐controlled pilot evaluation Link
D. Schaffler-Schaden et al. Medicine (Baltimore) 2020; 99(19): 2014. Comparison of high Tone Therapy and Transcutaneous Electrical Nerve Stimulation Therapy in Chemotherapy-Induced Polyneuropathy Link
A. Kubsik et al. National Library of Medicine 2022 The Influence of High Tone Power therapy on the Functional Status of Patients with Multiple Sclerosis Link
K. Kempf et al. The Open Pain Journal 2018; 11(1): 21-30 High-Tone External Muscle Stimulation for the Treatment of Chronic Sciatica - A Randomized Controlled Link
N. Shady et al. Turkish Journal of Physiotherapy and Rehabilitation, September 2021 32(3):14328-14333. Effect of High Tone Power Therapy on Carpal Tunnel Syndrome Patients: (randomized controlled trial) Link
AM Alshimy et al. European Journal of Molecular & Clinical Medicine 2020; 7(9): 269-275. Effect of High Tone Power Therapy on Neurophysiological Measures and Function Outcome in Patients with Diabetic Neuropathy Link

Mental Health

Author Source Title Links
I. Shmakova et al Balneo and PRM Research Journal http://dx.doi.org/10.12680/balneo.2021.462 Vol.12, No.4 December 2021 Evaluation of the impact of high-tone therapy on cognitive disorders and quality of life in the complex treatment of patients with comorbid pathology Link
M.-N. Liu et al. J Geriatr Psychiatry Neurol 2021; 34(1): 37-45. High-Frequency External Muscle Stimulation Reduces Depressive Symptoms in Older Male Veterans: A Pilot Study Link
K. D. Babov et al. Neurological Sciences volume 44, pages1039-1048 (2023). The effectiveness of high tone therapy in the complex rehabilitation of servicemen with -posttraumatic stress disorder complicated by traumatic brain injury Link

Soft Tissue Regeneration and  Muscle Strengthening

Author Source Title Links
Finn Schmetzer Deutsche berufsakademie sport und gesundheit (Bachlor Thesis) Testing of improved regeneration and increased strength through High Tone therapy Link
Katarzyna Ogrodzka-Ciechanowicz et al. PubMed 2021 Nov 23;22(1):975. Quadriceps Muscle Strength Recovery With the Use of High Tone Power Therapy After ACL Reconstruction: a Randomized Controlled Trial Link
Diego Serrano-Muñoz et al. Journal of NeuroEngineering and Rehabilitation (2018) 15:103 Effect of high-frequency alternating current transcutaneous stimulation over muscle strength: a controlled pilot study Link
DR.MITJA BRACIC HiToP® in Sports Training and Rehabilitation

Link Link

Diseases of the locomotor system (Arthrosis)

Author Source Title Links
Prof. Dr. Berthold Schneider Institute of Biometry, University of Medicine, Hannover (2003) Observation study Hightone therapy with the HiToP® device in case of diseases of the locomotor system Link

Metabolic Function     Vascular Health     Kidney Function

Author Source Title Links
H. Namvar et al. Journal of Modern Rehabilitation Effect of High-Tone External Muscle Stimulation (High-Tone Therapy) in Neuro-Musculoskeletal Disorders: A Narrative Review Link
Miroslava Peckova et al. Clinical Nephrology, Vol. 78 – No. Suppl. 1/2012 (S34-S36) Effects of high-tone External Muscle Stimulation on renal function in Healthy Volunteers Link
H. Ezz at Obay et al. International Journal of Recent Advances in Multidisciplinary Research. Vol. 09, Issue 08, Effect of High Tone Therapy on Selective Kidney functions in Hemodialysis Patients Link
B. Rose et al. Experimental and Clinical Endocrinology & Diabetes 2008; 116(10). Beneficial Effects of External Muscle Stimulation on Glycaemic Control in Patients with Type 2 Diabetes Link
B. Strempska et al. Clinical Nephrology 2013; 79(Suppl.1). The Effects of High-tone External Muscle Stimulation on Symptoms and Electrophysiological Parameters of Uremic Peripheral Neuropathy Link
L. Di Micco et al. G Ital Nefrol 2015; 32(5). Muscle Stimulation in elderly patients with CKD and sarcopenia Link
l. Spanidis et al. Diabetology and Metabolism 2016; 11 - FV29 External muscle stimulation differentiates circulating hematopoietic stem cells in diabetes patients Link
Rania Abdel Basit Abdel Moez et al. International Journal of Thin Film Science and Technology High Tone External Muscle Stimulation versus Aerobic Exercise on Endothelial Dysfunction and Walking Parameters in Peripheral Arterial Disease Link
B. Di Iorio et al. Clinical Nephrology 2014; 82(5). High-Tone external Muscle Stimulation in patients with acute kidney injury (AKI): beneficial effects on NO metabolism, asymmetric dimethylarginine, and endothelin-1. Link